RE-BONE®
RE-BONE® – A specific line of bone substitutes which supports tissue regeneration in bone and reconstructive surgery.
1. UBGEN is the only company producing biological bone obtained from bone tissue from cows less than 24 months old, grown in Italy.
2. The procedure for obtaining the biological bone respects the highest and most rigorous quality standards at the European level, imposed by Italian legislation.
3. Bone tissue is taken from young cows, carefully controlled in order to guarantee non-existent bovine spongiform encephalopathy (BSE) or "mad cow syndrome".
4. Bovine bone is processed at temperatures between -80°C + 121°C what it allows preserving the properties of the bone tissue and its non-ceramization.
RE-BONE®
RE-BONE® it is a product 100% Italian: the bones are of origin exclusively cattle (CE certificate). The technology for the antisepticization of bovine bones was developed by UBGEN in exclusive collaboration with the Biology Department of the University of Padua, using bones from cows fed natural food in Italian farms.
RE-BONE® is a natural material of bovine origin, obtained through a production process that respects the highest safety standardsa, which maintains the structure of the bone matrix and its osteoconductivity unchanged, offering at the same time a biocompatible material.
RE-BONE® is a bone substitute, very similar to human bone and therefore creates a favorable environment for osteoblast proliferation and chemotaxis, favoring neovascularization by maintaining the extracellular matrix proteins.
RE-BONE® biocompatibility
Laboratory studies have shown the regenerative effectiveness of the UBGEN decellularization method.
By cultivating mesenchymal stem cells derived from adipose tissue with RE-BONE® bone substitution, cell proliferation increased, resulting in up to 35% more cells after 14 days of culture.
RE-BONE® osteoinductive and osteoconductive capacity
Osteoinduction refers to the ability of the bone graft to induce undifferentiated stem cells from the surrounding tissues to differentiate into osteoblasts. This characteristic depends on the structure of the biomaterial: the more similar it is to the extracellular matrix of bone, the more osteoinductive the biomaterial is.
Osteoconduction refers to the situation in which the graft ensures the attachment, survival and proliferation of osteogenic cells, providing a the interconnected structure through which new cells can migrate and new vessels can form.
Sinus lifting with RE-BONE®
Studies on sinus lifting performed on animal and human models have shown that RE-BONE® induces excellent guided bone regeneration (GBR).
Fifteen days after implanting the granules RE-BONE in a maxillary sinus, some blood vessels have started to appear around the bone substitute, which is a fundamental requirement for the formation of a new bone because it ensures:
- the migration of osteoprogenitor cells in the graft;
- the differentiation of osteoprogenitor cells induced by the biomaterial;
- the movement of differentiated osteoblasts to deposit a new matrix.
The proximity of the osteoblasts to the biomaterial and the contact surface of the host tissue was noted, as well as the decontamination in the biomaterial structure with the deposition of collagen fibers.
Osteoinduction in vitro
The results of the in vitro osteoinduction analysis demonstrated the expression of bone markers in the undifferentiated cells after 21 days, and the histological analysis of the bone grafts after 30 days showed a significant presence of osteoblasts that penetrate into the pores of the biomaterial where it started to create a new collagen matrix.
The collagen deposited by osteoblasts contributes to WOVEN bone formation, i.e. a very dense collagen structure that will be mineralized in a later stage, ensuring the formation of mature bone.
Correct bone regeneration which can be seen from these images was made possible by the presence of numerous vessels near the biomaterial, which ensures the migration of osteoprogenitor cells, as well as the supply of nutrients and the elimination of waste.
Microporosity of the mineral structure
The specialized literature extensively presents the way in which microporosity of a biomaterial is a key factor for tissue regeneration. An increased contact surface between the graft and the cells of the surrounding tissue increases the probability of colonization by bone progenitor cells. Nanostructured biomaterials mimic the extracellular matrix of natural bones, creating a microenvironment that promotes cell adhesion, proliferation and differentiation.
In the images, the analyzes performed under a scanning electron microscope to evaluate the microporosity quality of the bone substitute RE-BONE®
Areas of applicability
Maintaining the alveolar implant site (postextractive) and the bone ridge.
Maxillary sinus surgery
Horizontal bone augmentation in the case of "2-wall" defects
Vertical bone augmentation in case of "2 walls" defects
Correction of bone deficiencies in peri-implantitis
Implant dehiscence defects
Correction of periodontal and fork defects of the teeth
